Domino's Ultimate Pepperoni Pizza, Medium 12" Hand Tossed Nutrition Facts
One serving of Domino's Ultimate Pepperoni Pizza, Medium 12" Hand Tossed (1 slice (1/5 pizza, 142 g)) has 420 calories, 17g of protein, 38g of carbohydrates (37g net carbs), 21g of fat and 960mg of sodium.
About 17% of its calories come from protein, 37% from carbs and 46% from fat.
How it compares with other specialty pizzas (per slice)
Among 44 items in Specialty Pizzas (per slice), it ranks #34 for fewest calories and #16 for most protein. Showing the closest items by calories.
| Item | Cal | Protein | Carbs | Fat | Sodium |
|---|---|---|---|---|---|
| MeatZZa Pizza, Medium 12" Hand Tossed | 420 | 18g | 38g | 21g | 1,000mg |
| Spinach & Feta Pizza, X-Large 16" Hand Tossed | 420 | 17g | 43g | 19g | 770mg |
| Ultimate Pepperoni Pizza, Medium 12" Hand Tossed | 420 | 17g | 38g | 21g | 960mg |
| Honolulu Hawaiian Pizza, X-Large 16" Hand Tossed | 430 | 19g | 47g | 18g | 1,010mg |
| Memphis BBQ Chicken Pizza, Medium 12" Hand Tossed | 410 | 18g | 44g | 17g | 800mg |
| Spicy Chicken Bacon Ranch Pizza, Large 14" Hand Tossed | 410 | 16g | 34g | 22g | 1,090mg |
| ExtravaganZZa Pizza, Small 10" Hand Tossed | 400 | 16g | 38g | 19g | 900mg |
| ExtravaganZZa Pizza, Medium 12" Hand Tossed | 440 | 18g | 40g | 22g | 1,040mg |
| Pacific Veggie Pizza, X-Large 16" Hand Tossed | 400 | 16g | 46g | 16g | 790mg |
| Philly Cheese Steak Pizza, X-Large 16" Hand Tossed | 400 | 17g | 43g | 17g | 920mg |
| Wisconsin 6 Cheese Pizza, X-Large 16" Hand Tossed | 440 | 19g | 46g | 19g | 880mg |
| The People's Pizza – Deluxe, Medium 12" Hand Tossed | 390 | 15g | 39g | 19g | 780mg |
| The People's Pizza – Deluxe, X-Large 16" Hand Tossed | 450 | 18g | 46g | 21g | 900mg |
| MeatZZa Pizza, Small 10" Hand Tossed | 390 | 16g | 38g | 19g | 870mg |
| Spicy Chicken Bacon Ranch Pizza, Small 10" Hand Tossed | 390 | 16g | 34g | 21g | 1,110mg |
Related Domino's guides
- High-Protein Domino's Orders, Ranked
- The Lowest-Calorie Meals at Domino's
- Domino's Keto and Low-Carb Guide
- Domino's Low-Sodium Guide
Add Ultimate Pepperoni Pizza, Medium 12" Hand Tossed to an order →
Nutrition Facts
Serving: 1 slice (1/5 pizza, 142 g)
% Daily Value*
- Total Fat 21g
- 27%
- Saturated Fat 9g
- 45%
- Trans Fat 0.5g
- Cholesterol 50mg
- 17%
- Sodium 960mg
- 42%
- Total Carbohydrate 38g
- 14%
- Dietary Fiber 1g
- 4%
- Total Sugars 3g
- Protein 17g
- 34%
* Percent Daily Values are based on a 2,000 calorie diet. Figures are estimates from published restaurant data; actual portions vary by location.
Source: Domino's Nutrition Guide, US (August 2026), checked August 2026.